FIELD: biotechnology.
SUBSTANCE: nucleic acid encoding a protein that is a pathogenic antigen, a histone stem-loop structure and a poly (A) or polyadenylation signal, a kit and a pharmaceutical composition containing one or more of said nucleic acid for treatment of an infectious disease, and a method for enhancement of expression of the encoded protein and the use of the said nucleic acid, kit or composition to enhance the encoded protein expression. The structure of the proposed nucleic acid, consisting of a combination of the poly (A) sequence or the polyadenylation signal elements in conjunction with the histone stem-loop structure, provides an increase in protein expression significantly above the level observed when using these elements separately.
EFFECT: proposed group of inventions can be used in medicine for treatment of infectious diseases.
26 cl, 24 dwg, 15 tbl, 11 ex
