ARTIFICIAL MOLECULES OF NUCLEIC ACIDS FOR IMPROVED EXPRESSION OF PROTEINS AND PEPTIDES Russian patent published in 2021 - IPC C12N15/62 C12N15/67 C12N15/85 C12N15/88 A61K38/00 A61K48/00 A61K39/00

Abstract RU 2750261 C2

FIELD: biotechnology.

SUBSTANCE: invention relates to the field of biotechnology, specifically, to an artificial molecule of a nucleic acid. The invention characterises a 5'UTR element produced from a TOP gene and capable of synergistically stabilising and improving production of an open frame-encoded readable protein/polypeptide in combination with a histone stem-loop with expression of the proposed artificial molecule of a nucleic acid. Optionally, the artificial molecule of a nucleic acid can additionally include a poly(A)-sequence, a polyadenylation signal and/or a 3'UTR.

EFFECT: technical result of the invention is production of an artificial molecule of a nucleic acid.

37 cl, 39 dwg, 6 tbl, 5 ex

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RU 2 750 261 C2

Authors

Tess Andreas

Dates

2021-06-25—Published

2013-03-27—Filed