NUCLEIC ACID COMPRISING OR CODING HISTONE STEM-LOOP AND POLY(A)-SEQUENCE OR POLYADENYLATION SIGNAL FOR INCREASING EXPRESSION OF ENCODED TUMOUR ANTIGEN Russian patent published in 2018 - IPC C12N15/67 C12N15/11 A61K31/7088 A61K31/7052 A61K39/00 A61P35/00

Abstract RU 2650795 C2

FIELD: biotechnology.

SUBSTANCE: present invention relates to biotechnology, specifically to an mRNA molecule comprising a coding region encoding a tumour antigen containing protein, at least one histone stem-loop and a poly(A)-sequence or a polyadenylation signal, and can be used in medicine. Invention provides a nucleic acid for increasing the expression of said encoded peptide or protein.

EFFECT: combining in the nucleic acid structure a polyadenylation signal and histone stem-loop structure due to the synergistic effect enables to increase the level of expression by several times compared to the level of each of said elements used separately.

25 cl, 27 dwg, 3 ex, 15 tbl

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RU 2 650 795 C2

Authors

Tess Andreas

Shlake Tomas

Probst Jokhen

Dates

2018-04-17—Published

2013-02-15—Filed