ARTIFICIAL NUCLEIC ACID MOLECULES FOR IMPROVED PROTEIN OR PEPTIDE EXPRESSION Russian patent published in 2018 - IPC C12N15/62 C12N15/67 C12N15/85 C12N15/88 A61K38/00 A61K48/00 A61K39/00

Abstract RU 2658490 C2

FIELD: biochemistry.

SUBSTANCE: invention relates to biotechnology, specifically to an artificial nucleic acid molecule. Invention further relates to the use of such an artificial nucleic acid molecule encoding therapeutic peptides or proteins in medicine for gene therapy and / or genetic vaccination.

EFFECT: synergistic effect due to the presence of the 5'-UTR element that is derived from the TOP gene and the 3'-noncoding region of the template RNA, stacked in the secondary step-loop structure, in the structure of an artificial nucleic acid, allows to increase the stability and prolong the expression of the encoded protein, in comparison with known analogues.

38 cl, 39 dwg, 6 tbl, 5 ex

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RU 2 658 490 C2

Authors

Tess Andreas

Dates

2018-06-21—Published

2013-03-27—Filed