METHOD OF PRODUCING 3-ACYL SUBSTITUTED 2-ARYL(HETERYL)-1H-INDOLE-5,6-DICARBONITRILES Russian patent published in 2017 - IPC C07D209/42 C07D209/12 C07D333/10 

FIELD: chemistry.

SUBSTANCE: invention relates to the method of producing new 3-acyl-substituted 2-aryl(heteryl)-1H-indole-5,6-dicarbonitriles in which R¹=COCH₃, or COC₂H_5, or COC₃H₇; R²=C6H5, or 4-CH₃C₆H₄, or 4-OCH₃C₆H₄, or 2-thienyl; R³=CH₃, or C₂H₅, or C₃H₇, which can be used as precursors for the synthesis of biologically active substances, drugs, phthalocyanines, hexatrienes. The method of producing a 1,2,3-tizamidine 1H-indole-5,6-dicarbonitriles is in the interaction of 2-substituted 1-hydroxy-1H-indole-5,6-dicarbonitriles with the appropriate anhydrides of aliphatic carboxylic acids in the presence of boronfluoridetrietherate, followed by cooling the resulting reaction mass, dissolving into a tenfold excess of cold water, filtering off the precipitated sludge 1,2,3-tizamidine 1H-indole-5,6-dicarbonitriles, washing with water, recrystallization from acetonitrile and air drying.

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EFFECT: increasing the yield.

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