GASTRORETENTIVE DOSAGE FORM AND DELIVERY SYSTEMS AND METHOD OF THEIR PRODUCTION USING FUNCTIONALIZED CALCIUM CARBONATE Russian patent published in 2018 - IPC A61K9/16 A61K9/20 A61K31/00 A61K47/02 

FIELD: pharmacology.

SUBSTANCE: group of inventions refers to instantly floating gastroretentive finished dosage form, represented as a tablet, mini-tablet, granules, cap or pellets and containing a pharmaceutically active ingredient, formulating aid and functionalized natural and/or synthetic calcium carbonate, which has Brunauer-Emmett-Teller surface area of 5-200 m²/g and is a product of reaction of the natural or synthetic calcium carbonate with pharmaceutically acceptable acid and carbon dioxide, formed by acid treatment and/or supplied from an external source, where the source of the natural calcium carbonate is isolated from marble, calcite, chalk, limestone, dolomite and/or their mixtures. The synthetic calcium carbonate is precipitated calcium carbonate, containing an aragonitic, vaterite or calcitic mineralogic crystal forms. It also relates to the method of its production and application of the functionalized natural and/or synthetic calcium carbonate for its production.

EFFECT: instantly floating properties of said finished dosage form and long stay in the stomach.

31 cl, 4 dwg, 3 tbl, 1 ex