DISPERSIBLE DOSAGE FORM Russian patent published in 2020 - IPC A61K9/16 A61K47/02 

FIELD: pharmaceutical industry.

SUBSTANCE: group of inventions relates to a method for preparing a quick-dispersed dosage form comprising the following steps: mixing material, containing at least one aerating agent and functionalised calcium carbonate, which is a reaction product of natural ground or precipitated calcium carbonate with carbon dioxide and with one or more acids in an aqueous medium, where carbon dioxide is formed in situ by acid treatment and/or is supplied from an external source; then, the mixture obtained at the previous stage is compacted into the belt by means of a roller press at a compression pressure of 200–2000 kPa (2–20 bar); said tape is granulated into granules; then said granules are sifted through at least one sieve with a certain size of cells. Also disclosed are granules for use as filler obtained by said method, and disclosed is use in this method of material containing functionalised calcium carbonate.

EFFECT: group of inventions ensures improvement of granules flowability, their free bulk density and packed density after compaction (compared to powder, from which these granules are obtained).

13 cl, 3 tbl, 3 dwg