METHOD FOR OXALATE URINARY STONE FORMATION PROCESS SIMULATION Russian patent published in 2018 - IPC G01N33/483 G09B23/28 

FIELD: medicine.

SUBSTANCE: method for oxalate urinary stone formation process simulation is based on stone growing in an artificially created human urine model environment, while for solution preparation, the following is used: CaCl₂⋅2H₂O - 7 mmol/l, MgSO₄⋅7H₂O - 4 mmol/l, NH₄Cl - 8 mmol/l, K₂SO₄ - 6 mmol/l, (NH₄)₂C₂O₄⋅H₂O - 2÷- 4 mmol/l, (NH₄)₃PO₄ - 10 mmol/l, K₂CO₃ - 7 mmol/l, KCl - 24 mmol/l, NaCl - 140 mmol/l, and distilled water. The synthesis is carried out at pH values of 4.00±0.05 for 72 hours at a temperature of 25°C.

EFFECT: use of the claimed method allows to identify the parameters that cause formation of oxalate urinary stone, and to create a model system by which it is possible to study the effectiveness of drugs action to prevent the formation and growth of oxalate urinary stones.

1 tbl, 2 dwg