METHOD FOR MODELING FORMATION OF PHOSPHATE URINARY STONE Russian patent published in 2022 - IPC G09B23/28 

FIELD: medicine.

SUBSTANCE: invention relates to the field of medicine, to methods for experimental modeling of pathological processes occurring in the urinary system. A method for modeling the formation of phosphate urinary stone is disclosed, based on growing the stone in an artificially created model environment of human urine, while preparing a solution, where distilled water and salts are used as initial components: CaCl₂·2H₂O - 7 mmol/l, MgSO₄·7H₂O - 4 mmol/l, NH₄Cl - 8 mmol/l, K₂SO₄ - 6 mmol/l, (NH₄)₂C₂O₄·H₂O - 1 mmol/l, (NH₄)₃PO₄ - 10 mmol/l, K₂CO₃ - 7 mmol/l, KCl - 24 mmol/l, NaCl - 140 mmol/l, synthesis is carried out at pH values of 6.45÷7.45 for 24 hours at a temperature of 37.0°C.

EFFECT: invention provides modeling of the crystallization of calcium phosphates in vitro in an environment with an electrolyte composition close to human urinary fluid.

1 cl, 2 dwg, 2 tbl