METHOD FOR COMPLEX EMPIRICAL ANTIBACTERIAL THERAPY OF IMPLANT-ASSOCIATED ORTHOPEDIC INFECTIONS Russian patent published in 2018 - IPC A61K31/665 A61K38/12 A61K45/06 A61P31/04 

FIELD: medicine.

SUBSTANCE: for complex empirical antibacterial therapy of implant-associated orthopedic infections, bone defect replacement with a cement spacer is performed. Then the wound is sutured. Antibacterial therapy is prescribed, which has simultaneous local and systemic effect on the focus of infection. At that, an antibacterial drug is added to the cement when the spacer is mixed and injected systemically after the operation. This antibacterial drug is allowed for regular use and is characterized by the presence of a freeze-dried form, thermostability, water solubility, a wide range of activity, including methicillin-resistant Staphylococcus. Moreover, the systemic therapy is complemented with an antibiotic having a synergic action in terms of leading pathogens of the implant-associated infection, but belonging to another group.

EFFECT: invention allows to increase the effectiveness of etiotropic antibacterial therapy for implant-associated orthopedic infections.

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