METHOD FOR PRODUCING ANTIMICROBIAL GEL Russian patent published in 2021 - IPC A61K9/00 A61K31/665 A61K31/7036 A61K47/58 A61P31/04 

FIELD: medicine.

SUBSTANCE: invention relates to the field of medicine, namely to biologically active gels used as antimicrobial agents (antibiotic delivery systems) for the prevention and treatment of infections in the field of surgical intervention in traumatology and orthopedics, including periprosthetic infections. The method for producing an antimicrobial gel involves mixing the initial components, which are polyvinylpyrrolidone in an amount of 10 to 30 wt.%, gentamicin sulfate, fosfomicin, and water, as well as irradiation of the mixture with γ-radiation using the ⁶⁰Co isotope to produce a gel with a viscosity of 1 to 20 Pa×s. Polyvinylpyrrolidone in an amount of 80-85 wt.% of the initial amount is pre-subjected to heat treatment at a temperature of 160-180ºC for 1-8 hours before mixing. Then, the resulting thermally crosslinked polyvinylpyrrolidone is dissolved in distilled water to obtain a polymer thixotropic gel, to which gentamicin sulfate in an amount of 0.5 to 1.5 wt.% and fosfomicin in an amount of 5.0 to 10 wt.% are added. Next, the remaining amount of thermally un-crosslinked polyvinylpyrrolidone is added to the resulting mixture, after which the mixture is subjected to γ-irradiation with a dose of 10-15 kGr.

EFFECT: invention provides for the production of a thixotropic reproducible hydrogel with an increased concentration of fosfomicin, which provides a prolonged effect of its antimicrobial activity for at least 9 days.

1 cl, 2 tbl, 1 dwg