FIELD: biotechnology.
SUBSTANCE: methods for production of a target antibody with modulated galactosylation (versions), methods for modulation of the target antibody galactosylation (versions) by culture medium optimisation are provided. The methods provide increasing the osmolality of the solution for culturing animal cells and/or asparagine addition to the solution at a certain point in time of the cell culturing process.
EFFECT: obtaining of the desired antibody population.
19 cl, 3 dwg, 8 tbl, 3 ex
| Title |
Year |
Author |
Number |
| METHOD FOR REDUCING ANTIBODY HETEROGENEITY AND METHOD FOR PRODUCING RELATED ANTIBODIES |
2012 |
- Srivastava Ruchika
- Khemdev Snekha Lakshmandas
- Bkhatnagar Ankur
- Desan Saravanan
- Dzhoel Anuj
- Ajer Kharish
|
RU2580020C2 |
| METHOD FOR PREPARING FED-BATCH ANTIBODY OR ITS FRAGMENT (VERSIONS) |
2007 |
- Pla Itskoatl' A
- Matuk Dzhozef K
- Fann Dzhon K
- Shul'Ts Kristof
- Roj Nikol' A
- Bruton Dehvid F
- Makintajr Dzhejms
- Chan Juj-Sian Dehvid
- Seevester Tomas
|
RU2518289C2 |
| METHOD OF PRODUCING RECOMBINANT HYALURONIDASE |
2021 |
- Park, Soon-Jae
- Kim, Kyuwan
- Yun, Sang Hoon
- Cho, Jeong Soo
- Park, Kibum
- Byun, Minsoo
- Song, Hyung Nam
- Kim, Ji-Sun
- Nam, Ki Seok
|
RU2822202C1 |
| METHOD FOR PRODUCING MONOCLONAL ANTIBODIES OF THERAPEUTIC PURPOSE BY CONTINUOUS CULTIVATION OF CHO CELLS |
2017 |
- Morozov Anton Nikolaevich
- Zakharov Zakhar Viktorovich
- Tyupa Dmitrij Valerevich
- Kochelabov Roman Aleksandrovich
|
RU2672318C1 |
| MODULATING CELL GROWTH AND GLYCOSYLATION WHEN PRODUCING RECOMBINANT GLYCOPROTEINS |
2015 |
- Popp Oliver
- Bokamp Nikola
- Drabner Georg
- Esslinger Shtefani
|
RU2712562C2 |
| MONOCLONAL ANTIBODY PREPARED USING INTEGRIN-ASSOCIATED PROTEIN, ITS FRAGMENT FAB, FAB' OR F(AB'), HYBRIDOMA PRODUCING MONOCLONAL ANTIBODY (VARIANT), ANTILEUKEMIC AGENT |
1998 |
- Fukusima Naosi
- Uno Sinsuke
|
RU2212413C2 |
| STRAIN OF HYBRID ANIMAL CELLS Mus musculus L - PRODUCER OF MONOCLONAL ANTIBODIES FOR EXPOSING VP40 PROTEIN OF EBOLA VIRUS, ZAIRE SUBTYPE (Mainga STRAIN) (VERSIONS), MONOCLONAL ANTIBODY PRODUCED BY SAID STRAIN (VERSIONS) AND SET FOR "SANDWICH" FORMAT IMMUNOENZYMOMETRIC TEST SYSTEM FOR EXPOSING VP40 PROTEIN OF EBOLA VIRUS, ZAIRE SUBTYPE (Mainga STRAIN) |
2008 |
- Kazachinskaja Elena Ivanovna
- Ivanova Alla Vladimirovna
- Kachko Alla Vasil'Evna
- Subbotina Ekaterina Leonidovna
- Chepurnov Aleksandr Alekseevich
- Razumov Ivan Alekseevich
- Loktev Valerij Borisovich
|
RU2395577C1 |
| METHOD FOR INCREASING SPECIFIC RATE AND PRODUCING IN EUKARYOTIC CELLS |
2015 |
|
RU2725191C2 |
| INFLIXIMAB, OPTIMISED GENE OF MONOCLONAL ANTIBODY (VERSIONS), RECOMBINANT CELL LINE, ANTIBODY PRODUCER AND METHOD FOR BIOSYNTHESIS THEREOF |
2013 |
- Shukurov Rakhim Rakhmankulyevich
- Lobanova Natalija Valentinovna
- Seregin Jurij Aleksandrovich
|
RU2549692C1 |
| IMPROVED CELL CULTURE MEDIUM |
2011 |
- Budakh Vol'Fgang Ehrnst Gustav
- Shassen Ehlen K.
- Dorsh Kerstin
|
RU2563353C2 |
