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2 643 671

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IPC

G09B23/28(2006-01-01)

A61K31/41(2006-01-01)

A61P27/02(2006-01-01)

(21) (22)

Application

2016148733, 2016-12-13

(24)

Start date

2016-12-13

(22)

Actual filing date

2016-12-13

(45)

Published

2018-02-05

(72)

Inventor

Peresypkina Anna AleksandrovnaPokrovskij Mikhail VladimirovichLevkova Elena AleksandrovnaGubareva Viktoriya OlegovnaPokrovskaya Tatyana GrigorevnaShabelnikova Anna SergeevnaNikitina Vladislava AleksandrovnaKochkarova Indira SultanovnaSharapov Mikhail ValerevichGureev Vladimir Vladimirovich

(73)

Holder

Federalnoe Gosudarstvennoe Avtonomnoe Obrazovatelnoe Uchrezhdenie Vysshego Obrazovaniya Gosudarstvennyj Natsionalnyj Issledovatelskij Universitet"

METHOD FOR RETINAL ISCHEMIA-REPERFUSION PREVENTION BY MINOXIDIL IN EXPERIMENT Russian patent published in 2018 - IPC G09B23/28 A61K31/41 A61P27/02

Abstract RU 2643671 C1

FIELD: medicine.

SUBSTANCE: method involves preliminary preconditioning by the drug via single intragastric administration of its solution to a laboratory animal. Subsequent modeling of retinal ischemia is carried out by mechanical pressure of 110 mm Hg on the anterior chamber of the eye for 30 minutes. Minoxidil in an amount of 0.5 mg/kg of animal body weight is used as a drug 60 minutes before simulation. The retinoprotective effect of minoxidil is assessed by electro-retinography after 72 hours of reperfusion.

EFFECT: pronounced correction of retinal ischemia-reperfusion in the experiment, which is confirmed by achievement of retinal microcirculation levels and restoration of the electrophysiological activity of the retina.

1 ex, 2 tbl

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RU 2 643 671 C1

Authors

Peresypkina Anna Aleksandrovna

Pokrovskij Mikhail Vladimirovich

Levkova Elena Aleksandrovna

Gubareva Viktoriya Olegovna

Pokrovskaya Tatyana Grigorevna

Shabelnikova Anna Sergeevna

Nikitina Vladislava Aleksandrovna

Kochkarova Indira Sultanovna

Sharapov Mikhail Valerevich

Gureev Vladimir Vladimirovich

Dates

2018-02-05—Published

2016-12-13—Filed