FIELD: medicine.
SUBSTANCE: method involves reproducing simulated gestosis experimentally by the intraperitoneal administration of N-nitro-L-arginine-methyl ester (L-NAME), an ADMA-like endothelial NO-synthase blocker in a dose of 25 mg/kg into pregnant female Wistar rats for 7 days from the 14th to 20th day of pregnancy. That is combined with the daily intragastric administration of Nicorandil through a probe in a dose of 10 mg/kg 2 times a day for 7 days from the 14th to 20th day of pregnancy.
EFFECT: method enables correcting endothelial dysfunction effectively; it has the prolonged anti-ischemic action, and is easy and safe to use.
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