FIELD: chemistry.
SUBSTANCE: continuous method for the preparation of tablets is described. According to the method of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamide)-3-methylpyridin-2-yl)benzoic acid is stirred with microcrystalline cellulose and croscarmellose sodium salt, a solution for granulation from water, polyvinylpyrrolidone and sodium lauryl sulfate is prepared. In a continuous twin-screw granulator, granules are produced, dried and milled, mixed milled granules with additional microcrystalline cellulose, croscarmellose sodium salt and magnesium stearate, compress the mixture into tablets. Tablets, obtained by using twin-screw wet granulation are characterized by a favorable dissolution rate.
EFFECT: tablets of the invention are useful in the treatment of cystic fibrosis.
4 cl, 28 dwg, 22 tbl
| Title |
Year |
Author |
Number |
| PHARMACEUTICAL COMPOSITIONS CONTAINING 3-(2, 2-DIFLUOROBENZO[d][1, 3]DIOXOL-5-YL)CYCLOPROPANECARBOXAMIDO)-3-METHYLPYRIDINE-2-YL)BENZOIC ACID, AND ADMINISTRATION THEREOF |
2011 |
- Vervejs Marinus Yakobus
- Alargova Rossitsa Georgieva
- Kaushik Ritu Rokhit
- Kadiyala Irina Nikolaevna
- Yang Kristofer Rajan
|
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2019 |
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- Haseltine, Eric L.
- Moskowitz, Samuel
- Robertson, Sarah
- Waltz, David
- Chen, Weichao George
|
RU2822220C2 |
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2013 |
- Inaba Khiroyuki
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|
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2014 |
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- Thomas, Vance, Hayden
- Warman, Martin, Paul
|
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| INJECTION OF DEUTERATED CFTR AMPLIFIERS |
2016 |
|
RU2761344C2 |
| PILL CONTAINING 1-(3-(2-(1-BENZOTHIOPHEN-5-YL)ETHOXY)PROPYL)AZETIDIN-3-OL OR ITS SALTS |
2016 |
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|
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2015 |
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| HIGH DOSAGE STRENGTH TABLETS OF RUCAPARIB |
2015 |
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| SOLID FORMS OF (R)-1-(2, 2-DIFLUOROBENZO[D][1, 3]DIOXOL-5-YL)-N-(1-(2,3-DIHYDROXYPROPYL)-6-FLUORO-2-(1-HYDROXY-2-METHYLPROPAN-2-YL)-1H-INDOL-5-YL) CYCLOPROPANECARBOXAMIDE |
2011 |
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2001 |
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RU2279273C2 |
