METHODS OF GLYCOGONJUGATION AND COMPOSITION Russian patent published in 2018 - IPC A61K47/50 A61P31/04 

Abstract RU 2645071 C2

FIELD: medicine.

SUBSTANCE: group of inventions relates to medicine, namely to vaccine prevention, and discloses a method for preparing a glycoconjugate comprising bacterial capsular polysaccharide conjugated to a carrier protein via (2-((2-oxoethyl)thio)ethyl)carbamate (eTEC) spacer, glycoconjugate, and the immunogenic composition containing said glycoconjugate.

EFFECT: inventions allow to obtain suitably blocked conjugates based on a carrier protein, which maintain the functional properties of the carrier and the conjugate itself retains the ability to induce the desired immune response.

16 cl, 15 tbl, 9 ex, 8 dwg

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RU 2 645 071 C2

Authors

Gu Tszyansin

Kim Chzhin-Khvan

Prasad A. Krishna

Yang Yu-Jin

Dates

2018-02-15Published

2013-08-12Filed