IMMUNOGENIC COMPOSITIONS CONTAINING CONJUGATED CAPSULE SACCHARIDE ANTIGENS AND THEIR USE Russian patent published in 2022 - IPC A61K39/00 A61K39/09 A61K47/64 A61K39/385 

FIELD: biotechnology.

SUBSTANCE: immunogenic composition is described for the prevention of a disease or condition related to S. pneumoniae, containing glycoconjugate based on S. pneumoniae serotype 22F. Glycoconjugate has molecular weight from 1000 KDa to 12,500 KDa and contains isolated capsule polysaccharide S. pneumoniae serotype 22F and a protein carrier. Activated polysaccharide of serotype 22F has molecular weight from 70 KDa to 700 KDa. A ratio (wt./wt.) of polysaccharide to the protein carrier is from 0.4 to 1.2. The specified glycoconjugate of serotype 22F contains at least 0.7 mM of acetate per mM of capsule polysaccharide of serotype 22F. The specified glycoconjugate of serotype 22F is obtained using reducing amination, and an oxidation degree of activated polysaccharide of serotype 22F is from 12 to 20. The specified protein carrier is CRM₁₉₇.

EFFECT: invention expands the arsenal of immunogenic compositions for the prevention of a disease or condition related to S. pneumoniae.

28 cl, 16 dwg, 25 tbl, 20 ex