FIELD: medicine; pharmacology.
SUBSTANCE: invention refers to pharmacology, namely to compounds of the following general formula, which exhibit antiarrhythmic activity. In said formula when R=C6H5, and n=0, then NR12=NC5H10 or NC4H8O; when R=C6H5OCH2, and n=1, then NR12=N(C2H5)2, NC4H8, NC5H10 or NC4H8O; when R=C6H5OCH2, and n=0, then NR12=NC5H10 or NC4H8O; when R=2,4-Cl2-C6H3OCH2, and n=1, then NR12=N(C2H5)2, NC4H8, NC5H10 or NC4H8O; when R=2,4-Cl2-C6H3OCH2, and n=0, then NR12=NC5H10 or NC4H8O, wherein NC4H8 means pyrrolidino, NC5H10 – piperidino, NC4H8O – morpholino. Invention also relates to a medicinal agent and a pharmaceutical composition, which include said compounds.
EFFECT: disclosed are N-(2-(2-(dialkylamino)ethoxy)ethyl)carboxamides and hydrochlorides thereof, having antiarrhythmic activity, and pharmaceutical compositions based thereon.
3 cl, 4 tbl, 3 dwg, 20 ex
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