FIELD: microbiology.
SUBSTANCE: invention relates to the cellular biology, namely to producing induced neural stem cells from differentiated cells. Method includes delivering, to a non-neuronal cell, a kit for inducing reprogramming, containing a SOX2 protein or a nucleic acid molecule encoding the SOX2 protein, and an HMGA2 protein or a nucleic acid molecule encoding the HMGA2 protein, or increasing the expression of the proteins in a cell followed by culturing.
EFFECT: invention allows screening a regeneration promoter or a regeneration inhibitor, individually selected for the patient's therapeutic agent, as well as provides a method of treating and preventing diseases caused by damage to neural stem cells.
19 cl, 31 dwg, 21 ex
