DRY EXTRACT FROM FUCUS ALGAE WITH ANTIOXIDANT ACTION AND THE METHOD OF ITS PRODUCTION Russian patent published in 2018 - IPC A61K36/03 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: invention relates to medical and therapeutic-preventive practices, to the chemical-pharmaceutical, food, and cosmetic industries. Difference in obtaining the claimed dry extract from fucus algae, which has an antioxidant effect,is that algae are used: Fucus vesiculosus, Fucus distichus and Fucus serratus; extraction of algae is carried out with a mixture of fructose, glucose, sucrose and water (in a molar ratio of 1:1:1:11) 20 % and water 80 % using microwave radiation with a power of 500–600 W for 10–15 minutes at a temperature of 40–60 °C, then the enzyme protosubtilin is added to the reaction mixture at a rate of 1–3 g per 100 g of extract and fermentation is performed with ultrasonic treatment at a frequency of 42 kHz at a temperature of 40 °C for 30 minutes; at the end of the process the enzyme is inactivated, the algae cake is separated, the liquid extract is treated with a flocculant at the rate of 0.5–1.5 g per 100 g of the extract, the precipitate of the flocculant is separated. As an extractant, a mixture of proline, malic acid and water (in a molar ratio of 1:1:3) 20 % and water 80 % is used. As a raw material for the production of dry extract from fucus algae, which has an antioxidant effect, fresh, frozen or dry algae thalli can be used. Hydromodule for fresh and frozen algae can be 1:1, for dry – 1:5. As a flocculant, chitosan or microcrystalline cellulose (MCC) can be used. Drying of the liquid extract can be carried out lyophilically or by means of a spray dryer. Dried extract from fucus algae, which has the antioxidant effect obtained by the above method, is a complex of biologically active substances (BAS) of the following composition: fucoidan 50–60 g, alginic acid 1–5 g, polyphenols 25–35 g, free amino acids 50–100 mg, ascorbic acid 0.5–1 g in 100 g of dry extract.

EFFECT: claimed invention ensures achievement of the indicated technical results, namely, ensuring the most complete extraction of biologically active substances of fucus algae and obtaining a dry extract from fucus algae with enhanced antioxidant activity and improved solubility in water.

7 cl, 1 dwg, 3 tbl