METHOD OF OBTAINING GLUCOSE-SENSITIVE POLYMER HYDROGELS Russian patent published in 2018 - IPC C08F220/54 C08F220/56 C08F2/38 A61K38/28 

FIELD: biochemistry.

SUBSTANCE: invention relates to the field of biochemistry and medicine, to a method for the preparation of glucose-sensitive polymeric hydrogels that can be used as carriers for controlled release of insulin upon the appearance of glucose. A process for the preparation of glucose-sensitive polymeric hydrogels is carried out by polymerization under the action of an oxidation-reduction initiator of an aqueous solution containing 0.15–0.5 % of N-(2-D-glucose)acrylamide, 3.0–5.0 % of acrylamide, 0.01–0.06 % of N, N-methylenebisacrylamide, 0.05–0.15 % of concanavalin A and 0.03–0.10 % of mercaptoacetic acid.

EFFECT: obtained hydrogel provides the release of an increased amount of insulin at the initial stage of the appearance of glucose in the subsequent regulated release in the subsequent time of action.

1 cl, 3 tbl, 7 ex