METHOD OF PREPARING GLUCOSE-SENSITIVE POLYMER HYDROGELS Russian patent published in 2010 - IPC C08F220/56 A61K38/28 C07K17/04 C07K17/08 

FIELD: chemistry.

SUBSTANCE: invention relates to chemistry of polymers, biochemistry and medicine, and specifically to a method of preparing glucose-sensitive polymer hydrogels used as carriers for controlled secretion of insulin. The glucose-sensitive polymer hydrogels are obtained from reaction of a glucose derivative with concanavalin A. The reaction is carried out through copolymerisation in an aqueous solution under the effect of a redox initiator of 0.1-2.0 wt % N-(2-D-glucose)acrylamide, 1-5 wt % acrylamide and 0.01-0.075 wt % N,N-methylenebisacrylamide in the presence of 5-20 wt % concanavalin A.

EFFECT: obtaining polymer hydrogels which can be insulin carriers, with no other components of the hydrogel being released into the surrounding medium.

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