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2 342 147

(13)

(51)

IPC

A61K31/727(2006-01-01)

A61K38/58(2006-01-01)

A61P7/02(2006-01-01)

(21) (22)

Application

2007127757/15, 2007-07-20

(24)

Start date

2007-07-20

(22)

Actual filing date

2007-07-20

(45)

Published

2008-12-27

(72)

Inventor

Valuev Lev IvanovichValuev Ivan L'VovichSytov Gennadij AlekseevichTalyzenkov Jurij Afanas'Evich

(73)

Holder

Ordena Trudovogo Krasnogo Znameni Institut Neftekhimicheskogo Sinteza Im. A.V. Topchieva Rossijskoj Akademii Nauk Gosudarstvennogo Uchrezhdenija)

METHOD FOR POLYMER HYDROGEL PRODUCTION, CONTAINING PHYSIOLOGICALLY ACTIVE SUBSTANCES Russian patent published in 2008 - IPC A61K31/727 A61K38/58 A61P7/02

Abstract RU 2342147 C1

FIELD: medicine; pharmacology.

SUBSTANCE: method consists in polymer hydrogel production, containing physiologically active substances, by physiologically active substance immobilisation in cross-linked polymer volume, modified with ovomucoid from duck egg-white; the cross-linked polymer being additionally modified with α-amylase inhibitor from wheat seed; as physiologically active substance heparin or hirudin is used. The cross-linked polymer modified with ovomucoid and α-amylase inhibitor is obtained by chemical modification of polymer with ovomucoid and α-amylase inhibitor mix, in proportion of 0.5 to 15 mg ovomucoid to 1 g swollen cross-linked polymer, and 0.5 to 5.0 mg α-amylase inhibitor to 1 g swollen cross-linked polymer.

EFFECT: hydrogels have anticoagulant activity, are eligible for peroral administration in prevention and treatment for cardiovascular disorders.

2 cl, 20 ex, 1 tbl

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RU 2 342 147 C1

Authors

Valuev Lev Ivanovich

Valuev Ivan L'Vovich

Sytov Gennadij Alekseevich

Talyzenkov Jurij Afanas'Evich

Dates

2008-12-27—Published

2007-07-20—Filed