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2 295 517

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IPC

C07C259/06(2006-01-01)

A61K31/16(2006-01-01)

A61P35/04(2006-01-01)

(21) (22)

Application

2005119520/04, 2005-06-24

(24)

Start date

2005-06-24

(22)

Actual filing date

2005-06-24

(45)

Published

2007-03-20

(72)

Inventor

Fedorov Boris SergeevichFadeev Mikhail Arsen'EvichKonovalova Nina PetrovnaSashenkova Tat'Jana Evgen'EvnaLarjukova Marina ViktorovnaAldoshin Sergej Mikhajlovich

(73)

Holder

Institut Problem Khimicheskoj Fiziki Ran Ran)

DERIVATIVES OF CARBOXYLIC ACIDS, INHIBITORS OF METASTASIS AND AGENTS ENHANCING CHEMOTHERAPEUTIC ACTIVITY OF ANTITUMOR PREPARATIONS, METHOD FOR ENHANCING EFFECTIVENESS OF CYTOSTATICS, METHOD FOR INHIBITION OF METASTASIZING PROCESS Russian patent published in 2007 - IPC C07C259/06 A61K31/16 A61P35/04

Abstract RU 2295517 C1

FIELD: organic chemistry, medicine, oncology.

SUBSTANCE: invention relates to using dicarboxylic acids of the general formula (2): R-CONH-OH (2) wherein R means -HO-HNCO, -HO-NHCOCH-(OH)CH(OH), -HOOC-CH₂CH₂, -HO-OCCH=CH as inhibitors of metastasis and agents enhancing chemotherapeutic activity of antitumor preparations. Also, invention relates to a method for enhancing effectiveness of cytostatics in carrying out cytostatic chemotherapy of tumors. Method is carried out by using cytostatics in combination with derivatives of dicarboxylic acids of the formula (2). Also, invention relates to a method for inhibition of metastasizing process. Method is carried out by effect of the known cytostatics and derivatives of dicarboxylic acid of the formula (2) on tumor. Proposed substances provide enhancing antitumor and anti-metastatic activity of known cytostatics based on using derivatives of dicarboxylic acids.

EFFECT: valuable medicinal properties of agents and preparations, enhanced effectiveness of metastasizing inhibition.

4 cl, 4 dwg, 7 ex

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RU 2 295 517 C1

Authors

Fedorov Boris Sergeevich

Fadeev Mikhail Arsen'Evich

Konovalova Nina Petrovna

Sashenkova Tat'Jana Evgen'Evna

Larjukova Marina Viktorovna

Aldoshin Sergej Mikhajlovich

Dates

2007-03-20—Published

2005-06-24—Filed