PHYSICAL METHOD OF COMBATING MICROORGANISMS Russian patent published in 2018 - IPC A61K31/695 A61P31/02 A61K9/14 A61K9/70 

FIELD: antimicrobial treatment.

SUBSTANCE: group of inventions relates to the field of antimicrobial treatment. Antimicrobial treatment method comprises applying an antimicrobial composition to form an antimicrobial film with a quaternary cation. Composition comprises an organosilicon diquaternary ammonium salt of formula (I) (R¹R²R³N⁺X^-)–R⁵–(R¹R²R³N⁺X^-) (I), wherein each R1 is a C8-18 alkyl group, a C8-18 alkenyl group or a C8-18 alkynyl group; each R2 and R3 is methyl or ethyl; R5 is C3-10 alkylene which is substituted in the β-position or more distant position by means of three (C1-3 alkoxy) silyloxy or tri (C1-3 alkoxy) silyl-C1-6 alkoxy; and each X- represents a pharmaceutically acceptable counteranion; and at least one excipient. Thickness of the antimicrobial film and the diameter of the polymer particles are in the range from 1 nm to 1000 nm, and the application provides a zeta potential on the surface of the body from +40 mV to +80 mV. Organosilicon diquaternary ammonium salt, an antimicrobial composition, is also disclosed, as well as the method of preventing and treating various local infections in humans.

EFFECT: group of inventions provides for the destruction of pathogenic microorganisms, as well as an effective way of preventing and treating various infections.

30 cl, 3 dwg, 8 tbl