FIELD: medicine.
SUBSTANCE: described herein are micronised powder particles of colistimethate sodium, wherein at least 50% by volume of the micronised particles have a diameter of less than 7 mcm, but not less than 3 mcm and the powder has a total moisture content of 5 to 10 % by weight, for use in the treatment of a pulmonary infection by powder inhalation, wherein the colistimethate sodium is not separated into components. Micronised powder particles of colistimethate sodium are placed in a container which is a hard gelatin capsule. Micronised powder particles of colistimethate sodium are useful in the treatment of infections caused by gram-negative bacteria, particularly in patients suffering from cystic fibrosis.
EFFECT: invention improves the stability and performance of colistimethate sodium.
19 cl, 7 dwg, 5 tbl, 9 ex
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