FIELD: pharmaceutics.
SUBSTANCE: invention relates to the field of pharmaceutics, namely to an oral solid dosage form for the inhibition of Abl tyrosine kinase, containing a mixture of therapeutically effective amount of a compound of the Formula I and a fusible polymer carrier, where the fusible polymer carrier is grafted copolymer of polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol, where the specified mixture is an amorphous dispersion, and where the specified amorphous dispersion is in a grounded form, in which all particles have a size of less than 500 micrometers.
EFFECT: provision of bioavailability and stability of an oral solid dosage form based on a compound of the Formula I and a fusible polymer carrier.
Formula I
5 cl, 9 dwg, 4 tbl, 5 ex
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