FIELD: pharmaceutics.
SUBSTANCE: invention relates to an oral solid dosage form for inhibiting tyrosine kinase Abl, containing a mixture of a compound of Formula I
Formula I and a fusible polymer carrier; where the fusible polymer carrier is a polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol copolymer; and where said mixture is an amorphous dispersion obtained by hot melt extrusion.
EFFECT: what is prepared is an oral solid dosage form for inhibiting tyrosine kinase Abl, which has improved bioavailability and stability.
4 cl, 4 dwg, 2 tbl, 4 ex
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