METHOD FOR OBTAINING MAGNETITE NANOPARTICLES EPITAXIALLY GROWN ON GOLD NANOPARTICLES Russian patent published in 2018 - IPC C01G49/08 B05D5/12 B82B3/00 B82Y5/00 B82Y30/00 B82Y40/00 A61K33/26 A61K49/06 A61K49/18 

FIELD: chemistry.

SUBSTANCE: invention relates to inorganic chemistry and relates to method for producing magnetite nanoparticles (Fe₃O₄), epitaxially grown on gold nanoparticles, which can be used in magnetic resonance imaging as a contrast agent, in magnetic separation, magnetic hyperthermia, targeted delivery of drugs using an external magnetic field. Method for obtaining magnetite nanoparticles epitaxially grown on gold nanoparticles includes heating to 120 °C in an inert gas atmosphere with stirring a mixture of diphenyl ether, oleic acid, oleylamine and 1,2-hexadecanediol, the introduction of iron in the pentacarbonyl mixture, maintaining the resulting mixture, followed by the introduction of a solution containing a mixture of hydrochloric acid trihydrate and oleylamine in diphenyl ether, pre-aged in an inert gas atmosphere, reheating at a temperature of 250–260 °C, maintaining the heated mixture at a temperature of 250–260 °C for 25–30 minutes, its subsequent cooling to room temperature, conducted in an inert gas atmosphere, maintaining the mixture in the presence of air, adding a monohydric alcohol to the mixture and separating the magnetite nanoparticles by centrifugation. Structure of the resulting nanoparticles resembles a dumbbell in which a magnetite nanoparticle is chemically bonded to a gold nanoparticle.

EFFECT: proposed method allows to obtain magnetite nanoparticles with a diameter of 4±1 nm, epitaxially grown on gold nanoparticles with a diameter of 2±1 nm, which allows them to penetrate inside the cells and their nuclei.

1 cl, 3 ex