FIELD: chemistry.
SUBSTANCE: invention relates to ethyl derivatives of 2-[{(piperazin-1-yl)carbonyl}amino]-5,6-dihydro-4H-cyclopenta[b]thiophenyl-3-carboxylate of general formula:
,
where R1 – (2R)-3-ethoxypropan-2-ol or ethoxycarbonyl or hydroxyethyl or (2S)-2-butan-1-ol, R2 – H or methyl.
EFFECT: selective inhibition of glyceraldehyde-3-phosphate dehydrogenase of mycobacteria without affecting the activity of homologous enzymes in humans and animals, as well as suppression of the growth of the causative agent of tuberculosis – Mycobacterium tuberculosis, strain H37Rv.
1 cl, 1 tbl, 8 ex
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