Show metadata Hide metadata

(19)

(11)

2 784 399

(13)

(51)

IPC

C07D295/192(2006-01-01)

C07D307/70(2006-01-01)

A61P31/06(2006-01-01)

(21) (22)

Application

2021133251, 2021-11-15

(24)

Start date

2021-11-15

(22)

Actual filing date

2021-11-15

(45)

Published

2022-11-24

(72)

Inventor

Dobrikov GeorgiDogonadze Marine ZaurievnaSoloveva Natalya SergeevnaVyazovaya Anna AleksandrovnaVlcheva VioletaMokrousov Igor VladislavovichZhuravlev Vyacheslav Yurevich

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Uchrezhdenie Nauchno-Issledovatelskij Institut Ftiziopulmonologii" Ministerstva Zdravookhraneniya Rossijskoj Federatsii Niif" Minzdrava Rossii)Federalnoe Byudzhetnoe Uchrezhdenie Nauki Nauchno-Issledovatelskij Institut Epidemiologii I Mikrobiologii Im. Pastera" Federalnoj Sluzhby Po Nadzoru V Sfere Zashchity Prav Potrebitelej I Blagopoluchiya Cheloveka Nii Epidemiologii I Mikrobiologii Imeni Pastera)

(4-(3-HYDROXYPHENYL)PIPERAZINE-1-YL)(5-NITROFURAN-2-YL)METHANON, WHICH HAS ANTITUBERCULAR ACTIVITY AGAINST THE CAUSATIVE AGENT OF MULTIDRUG-RESISTANT TUBERCULOSIS, AND THE METHOD FOR ITS PREPARATION Russian patent published in 2022 - IPC C07D295/192 C07D307/70 A61P31/06

Abstract RU 2784399 C1

FIELD: chemistry.

SUBSTANCE: invention relates to a new compound: (4-(3-hydroxyphenyl)piperazine-1-yl)(5-nitrofuran-2-yl)methanone of formula 1, which has anti-tuberculosis activity against the causative agent of multidrug-resistant tuberculosis, and the method for its preparation.

EFFECT: new compound has been obtained that has antimycobacterial activity both against the sensitive standard strain of M. tuberculosis H₃₇Rv and drug-resistant strains, including those with multiple and broad drug resistance.

3 cl, 5 dwg, 1 tbl, 2 ex

Similar patents RU2784399C1

Title	Year	Author	Number
METHOD FOR DETECTION OF MYCOBACTERIUM TUBERCULOSIS BEIJING 1071-32-CLUSTER GENOTYPE IN REAL-TIME FORMAT	2021	Vyazovaya Anna Aleksandrovna Sinkov Vyacheslav Vladimirovich Pasechnik Oksana Aleksandrovna Badleeva Mariya Vladimirovna Khromova Polina Andreevna Yarusova Irina Vladimirovna Zhdanova Svetlana Nikolaevna Gerasimova Alena Andreevna Soloveva Natalya Sergeevna Zhuravlev Vyacheslav Yurevich Ogarkov Oleg Borisovich Mokrousov Igor Vladislavovich	RU2768021C1
METHOD OF DETECTING PHYLOGENETIC SUBLINES OF BEIJING MYCOBACTERIUM TUBERCULOSIS GENOTYPE IN REAL TIME FORMAT	2020	Mokrousov Igor Vladislavovich Vyazovaya Anna Aleksandrovna Gerasimova Alena Andreevna Soloveva Natalya Sergeevna Zhuravlev Vyacheslav Yurevich	RU2743365C1
METHOD OF DETECTING MYCOBACTERIUM TUBERCULOSIS BEIJING 14717-15-CLUSTER GENOTYPE	2022	Mokrousov Igor Vladislavovich Vyazovaya Anna Aleksandrovna Badleeva Mariya Vladimirovna Yarusova Irina Vladimirovna Khromova Polina Andreevna Sinkov Vyacheslav Vladimirovich Zhdanova Svetlana Nikolaevna Gerasimova Alena Andreevna Soloveva Natalya Sergeevna Tatarintseva Marina Petrovna Zhuravlev Vyacheslav Yurevich Pasechnik Oksana Aleksandrovna Ogarkov Oleg Borisovich	RU2812351C1
METHOD FOR DETECTING MYCOBACTERIA TUBERCULOSIS CENTRAL ASIAN EPIDEMIC CLUSTER BEIJING GENOTYPE	2019	Mokrousov Igor Vladislavovich Shitikov Egor Aleksandrovich Vyazovaya Anna Aleksandrovna Skiba Yurij Aleksandrovich Malakhova Majya Vladimirovna Bespyatykh Yuliya Andreevna Soloveva Natalya Sergeevna Zhuravlev Vyacheslav Yurevich	RU2735415C1
COMPOUND 1-[(5-NITROFURAN-2-YL)CARBONYL]-2'-CYCLOHEXYL-1H,7'H-SPIRO[AZETIDINE-3,5'-FURO[3,4-D]PYRIMIDINE], HAVING ANTI-TUBERCULOSIS ACTIVITY AGAINST MULTIDRUG-RESISTANT TUBERCULOSIS AGENT, AND METHOD FOR PRODUCTION THEREOF	2023	Lukin Aleksej Yurevich Vinogradova Tatyana Ivanovna Dogonadze Marine Zaurievna Vinogradova Lyubov Vladimirovna Komarova Kristina Yurevna Darin Dmitrij Viktorovich Lavrova Anastasiya Igorevna Postnikov Evgenij Borisovich Sychev Aleksandr Vladimirovich Yablonskij Petr Kazimirovich	RU2825647C1
METHOD FOR DETECTION OF ISOLATES MYCOBACTERIUM TUBERCULOSIS BEIJING 94-32-CLUSTER IN REAL TIME FORMAT	2017	Mokrousov Igor Vladislavovich Vyazovaya Anna Aleksandrovna Chernyaeva Ekaterina Nikolaevna Soloveva Natalya Sergeevna Narvskaya Olga Viktorovna Zhuravlev Vyacheslav Yurevich	RU2689800C1
1-[(5-NITROFURAN-2-YL)CARBONYL]-2'-PROPYL-1H,7'H-SPIRO[AZETIDINE-3,5'-FURO[3,4-D]PYRIMIDINE], HAVING ANTI-TUBERCULOSIS ACTIVITY IN WITH RESPECT TO MULTIDRUG-RESISTANT TUBERCULOSIS AGENT, AND METHOD FOR PRODUCTION THEREOF	2023	Lukin Aleksej Yurevich Vinogradova Tatyana Ivanovna Dogonadze Marine Zaurievna Vinogradova Lyubov Vladimirovna Komarova Kristina Yurevna Darin Dmitrij Viktorovich Zabolotnykh Natalya Vyacheslavovna Lavrova Anastasiya Igorevna Postnikov Evgenij Borisovich Glukhov Dmitrij Aleksandrovich Sychev Aleksandr Vladimirovich Yablonskij Petr Kazimirovich	RU2824817C1
1-[(5-NITROFURAN-2-YL)CARBONYL]-2'-PHENYL-1H,7'H-SPIRO[AZETIDINE-3,5'-FURO[3,4-D]PYRIMIDINE], HAVING ANTI-TUBERCULOSIS ACTIVITY IN WITH RESPECT TO MULTIDRUG-RESISTANT TUBERCULOSIS AGENT, AND METHOD FOR PRODUCTION THEREOF	2023	Lukin Aleksej Yurevich Vinogradova Tatyana Ivanovna Dogonadze Marine Zaurievna Vinogradova Lyubov Vladimirovna Komarova Kristina Yurevna Darin Dmitrij Viktorovich Zabolotnykh Natalya Vyacheslavovna Lavrova Anastasiya Igorevna Postnikov Evgenij Borisovich Glukhov Dmitrij Aleksandrovich Sychev Aleksandr Vladimirovich Yablonskij Petr Kazimirovich	RU2824815C1
STRAIN MYCOBACTERIUM TUBERCULOSIS 326/18/47 B-9673 FOR EVALUATION OF THE EFFECTIVENESS OF ANTI-TB DRUGS AND DISINFECTANTS	2022	Panova Anna Evgenevna Gracheva Aleksandra Nikolaevna Vinokurov Anatolij Sergeevich Lagutkin Denis Anatolevich Kazyulina Anastasiya Aleksandrovna Bajrakova Aleksandra Lvovna Vasileva Irina Anatolevna	RU2785409C1
COMPOUND OF 8-(4-METHYL-4H-1,2,4-TRIAZOL-3-YL)-6-(METHYLSULPHONYL)-2-(5-NITRO-2-FUROYL)-2,6-DIAZASPIRO[3.4]OCTANE, HAVING ANTI-TUBERCULOSIS ACTIVITY AGAINST MULTIDRUG-RESISTANT TUBERCULOSIS AGENT, AND METHOD FOR PRODUCTION THEREOF	2023	Lukin Aleksej Yurevich Vinogradova Tatyana Ivanovna Dogonadze Marine Zaurievna Komarova Kristina Yurevna Vinogradova Lyubov Vladimirovna Darin Dmitrij Viktorovich Lavrova Anastasiya Igorevna Postnikov Evgenij Borisovich Sychev Aleksandr Vladimirovich Yablonskij Petr Kazimirovich	RU2825646C1

RU 2 784 399 C1

Authors

Dobrikov Georgi

Dogonadze Marine Zaurievna

Soloveva Natalya Sergeevna

Vyazovaya Anna Aleksandrovna

Vlcheva Violeta

Mokrousov Igor Vladislavovich

Zhuravlev Vyacheslav Yurevich

Dates

2022-11-24—Published

2021-11-15—Filed