GENETIC TEST FOR LIVER COPPER ACCUMULATION IN DOGS Russian patent published in 2018 - IPC C12Q1/68 

FIELD: chemistry.

SUBSTANCE: inventions relate to a method of testing a dog to determine the susceptibility of the dog to liver copper accumulation by detecting presence of a certain polymorphism, the use of such polymorphism to determine the susceptibility of the dog to liver copper accumulation, a method of testing a dog and a selection method. Disclosed methods or uses include (i) genotyping a DNA sample from a dog on one or more polymorphisms selected from Chr22_3167534 (represented by position 101 in SEQ ID NO: 144), the presence of allele A indicates susceptibility to liver copper accumulation, Chr22_3135144 (represented by position 101 in SEQ ID NO: 145), the presence of allele G indicates susceptibility to liver copper accumulation, and the repetition of CGCCCC in the chromosomal position 22:3135287, the presence of at least one additional repeat indicates susceptibility to liver copper accumulation using a specific binding agent selected from a probe or a combination of primers and which is capable of detecting or facilitating the detection of a selected polymorphism, and (ii) determining, based on the results of the genotyping stage, whether the dog is susceptible to liver copper accumulation.

EFFECT: inventions enable to identify dogs with a risk of developing or which are not protected from such diseases or pathological conditions of the liver as chronic hepatitis, cirrhosis or liver failure.

17 cl, 10 dwg, 21 tbl, 6 ex