FIELD: chemistry.
SUBSTANCE: invention relates to methods and intermediates for the preparation of spiroindolone compounds, such as (1'R,3'S)-5,7'-dichloro-6'-fluoro-3'-methyl-2',3',4',9'-tetrahydrospiro[indoline-3,1'-pyrido[3,4-b]indol-2-one, and their salts, hydrates and solvates. Method comprises enzymatic transamination of a compound of formula I into a compound of formula II using an enzyme represented by SEQ ID NO:134. 
(II) 
(I).
EFFECT: method makes it possible to increase the synthesis efficiency of the chiral amine intermediate.
12 cl, 12 ex
| Title | Year | Author | Number |
|---|---|---|---|
| NOVEL TRANSAMINASES AND A METHOD FOR DEAMINATION AN AMINO COMPOUND USING IT | 2016 |
|
RU2718778C2 |
| METHOD FOR PRODUING 2,4-DIHYDROXYBUTYRATE | 2013 |
|
RU2645260C2 |
| 3-(5-AMINO-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND USE THEREOF IN TREATING DISEASES ASSOCIATED WITH ZINC FINGER PROTEIN 2 OF IKAROS (IKZF2) FAMILY | 2019 |
|
RU2815714C2 |
| 3-(5-HYDROXY-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASES ASSOCIATED WITH ZINC FINGER PROTEIN 2 (IKZF2) OF THE IKAROS FAMILY | 2019 |
|
RU2797559C2 |
| HUMAN EZH2 INHIBITORS AND METHODS FOR USE THEREOF | 2013 |
|
RU2704445C2 |
| METHODS OF TREATING CANCER | 2013 |
|
RU2677276C2 |
| ENZYMATIC SYNTHESIS OF 4'-ETHYNYL NUCLEOSIDE ANALOGUES | 2019 |
|
RU2816846C2 |
| COMPOSITIONS AND METHODS FOR TREATING AND PREDICTING PULMONARY CANCER | 2001 |
|
RU2311920C2 |
| AGONIST OF THE GLUCOCORTICOID RECEPTOR AND ITS IMMUNOCONJUGATES | 2017 |
|
RU2745748C2 |
| CTLA-4 VARIANTS | 2013 |
|
RU2671465C2 |
