FIELD: biotechnology.
SUBSTANCE: method for producing a foot-and-mouth disease virus (FMDV) VP2 protein mutant, characterised in that the VP2 protein mutant is prepared by replacing at least one parenteral amino acid αA helix of the VP2 protein with an amino acid selected from the group consisting of: Q, N, V, I, F, Y, W and H, to obtain αA-helix, different from wild-type αA-helix, wherein the mutants are selected from the group consisting of: 1) mutants H87V, V90N, Y91F, S93H, S93Y, S93F, S93W, S93Q, L94V, S97V, S97I, S97Q and Y98F of serotype O; 2) mutants H93F and H93Q of serotype A; 3) mutants S93H, S93Y, S93W, S93F and Y98F of serotype SAT-2, where all position numbers are indicated in accordance with the amino acid numbering used in SEQ ID NO: 1.
EFFECT: invention widens the range of means for preventing foot and mouth disease.
1 cl, 10 dwg, 1 tbl, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| STRUCTURE | 2010 |
|
RU2565537C2 |
| FMDV VACCINES BASED ON A RECOMBINANT ADENOVIRAL VECTOR AND USE THEREOF | 2017 |
|
RU2725495C2 |
| FMDV-E2 FUSION PROTEINS AND USE THEREOF | 2016 |
|
RU2714428C2 |
| FMDV RECOMBINANT VACCINES AND USE THEREOF | 2015 |
|
RU2745373C2 |
| VACCINES CONTAINING GENETIC VARIANTS OF CANINE PARVOVIRUS | 2008 |
|
RU2519210C2 |
| POLYEPITOPE PROTEIN COMPOSITION FOR INDUCING IMMUNE RESPONSE AGAINST FOOT-AND-MOUTH DISEASE VIRUS | 2010 |
|
RU2453557C1 |
| REASSORTANT BTV AND AHSV VACCINES | 2013 |
|
RU2656187C2 |
| POLYEPITOPE PROTEIN, NUCLEOTIDE SEQUENCE CODING POLYEPITOPE PROTEIN, PLASMID WITH SEQUENCE CODING POLYEPITOPE PROTEIN, AND PREPARATION OF POLYEPITOPE PROTEIN FOR INDUCTION OF IMMUNE RESPONSE ON MURRAIN VIRUS | 2010 |
|
RU2467014C2 |
| VACCINE COMPOSITION AGAINST TYPE A FOOT-AND-MOUTH DISEASE VIRUS | 2018 |
|
RU2778095C2 |
| METHOD FOR INDIRECTLY DETERMINING THE TITER OF THE INFECTIOUS ACTIVITY OF FMDV IN NON-INACTIVATED RAW MATERIALS FOR VACCINES USING A MATHEMATICAL DOUBLE DIFFERENTIAL OF THE CROSSING POINT DATA DURING AMPLIFICATION OF VIRAL CDNA | 2022 |
|
RU2793900C1 |
