FIELD: pharmaceutics.
SUBSTANCE: invention relates to the chemical and pharmaceutical industry, and more particularly to a pharmaceutical composition for preventing and treating HIV infection. Pharmaceutical composition contains a HIV protease inhibitor representing ritonavir and magnesium aluminometasilicate in a weight ratio of 1:(0.5–1.5). Magnesium aluminometasilicate is Neusilin®. Ritonavir includes polymorphic form 1, polymorphic form 2, or combinations thereof. Pharmaceutical composition is prepared in solid form.
EFFECT: composition, according to the invention, using magnesium aluminometasilicate Neusilin® provides close solubility characteristics, regardless of the polymorphic form of ritonavir used.
9 cl, 1 tbl, 2 ex
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Authors
Dates
2018-08-06—Published
2017-03-20—Filed