WAYS TO INCREASE EXPRESSION OF NGN3 AND NKX6.1 IN PANCREATIC ENDOCRINE CELLS Russian patent published in 2018 - IPC C12N5/71 C12N5/74

Abstract RU 2664864 C1

FIELD: biotechnology.

SUBSTANCE: invention relates to cell biology and biotechnology, namely to a method for increasing expression of NGN3 and NKX6.1 in a population of cells of the endocrine pancreatic line. Method includes differentiating the cells of the definitive endoderm line into cells of the pancreatic endoderm line with subsequent their differentiation into the cells of the endocrine line of the pancreas.

EFFECT: invention allows to increase expression of the genes NGN3 and NKX6.1 in the endocrine pancreatic cell population.

10 cl, 8 tbl, 3 ex

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RU 2 664 864 C1

Authors

Devis Dzhanet

Parmenter Kristin

Ditolvo Kevin

Dates

2018-08-23—Published

2010-12-16—Filed