FIELD: medicine.
SUBSTANCE: group of inventions relates to quantum-dot spectrometers for use in biomedical devices. Biomedical device, according to the first embodiment comprises energization element including a first and a second current collector, a cathode, an anode and an electrolyte, quantum-dot spectrometer including a quantum-dot light emitter, a photodetector, and a means of communicating information from the quantum-dot spectrometer to a user, wherein the quantum-dot spectrometer is powered by the energization element, and an insert device, wherein the insert device contains the energization element and the quantum-dot spectrometer, and wherein the insert device isolates the energization element from a biomedical environment in which the biomedical device operates. In the second embodiment, the device has energization element, external encapsulation boundary, wherein at least a portion of the boundary forms a reentrant cavity, wherein a sidewall of the cavity allows light to pass through in a selected spectral band, quantum-dot light emitter installed to emit light through one side of the sidewall of the cavity through an intervening space of the cavity and through a distal side of the sidewall of the cavity, photodetector installed on the distal side of the cavity within the external encapsulation boundary, radio frequency transceiver, and an analog-to-digital converter, wherein a signal from the photodetector is converted to a digital data value that is transmitted outside the biomedical device by the radio frequency transceiver. In the third embodiment, the biomedical device comprises energization element, external encapsulation boundary, wherein at least a portion of the boundary comprises an electrically controlled pore operative to allow a fluid sample to pass into the biomedical device from an external region, microfluidic processing chip operative to mix the fluid sample with a reagent comprising an analyte specific dye, quantum-dot light emitter installed to emit light through a portion of the microfluidic processing chip, photodetector installed on a distal side of the microfluidic processing chip from the quantum-dot light emitter, wherein light emitted by the quantum-dot light emitter proceeds through a top surface of the microfluidic processing chip, through a sample analysis region of the microfluidic processing chip, through a bottom surface of the microfluidic processing chip and into the photodetector; radio frequency transceiver, and analog-to-digital converter. Method of analyzing analytes comprising the steps of fabricating a quantum-dot light emitter and a photodetector onto the biomedical device, connecting them to an integrated circuit controller within the biomedical device wherein the integrated circuit controller is capable of directing a functionality of the quantum-dot emitter and photodetector, emitting a narrow wavelength band from the quantum-dot light emitter, receiving transmitted photons into the photodetector and analyzing an absorbance of an analyte based on an intensity of photons received.
EFFECT: use of inventions provides a wider range of quantum-dot spectroscopy tools to perform personalized bioanalysis.
20 cl, 20 dwg
