COMPOUND HAVING AGONISTIC ACTIVITY TO SOMATOSTATIN RECEPTOR AND MEDICINAL USE THEREOF Russian patent published in 2018 - IPC C07D401/04 A61K31/4545 A61P1/00 A61P5/08 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: invention relates to a compound of formula (I)

wherein R¹ represents (1) a halogen atom, (2) a cyano group, (3) C_1-4-alkyl, (4) C_1-4-alkoxy or (5) C_3-8-cycloalkyl, where C_1-4-alkyl, C_1-4-alkoxy and C_3-8-cycloalkyl can be respectively and independently substituted with 1 to 3 halogen atoms and/or cyano groups; p is an integer 0–2; when p is 2, plurality of R¹ may be the same or different; R² and R³ respectively and independently represent a hydrogen atom or C_1-4-alkyl; R⁴ represents a hydrogen atom; or R² and R⁴ together with atom with which R² and R⁴ are linked, may form a 5- to 8-membered nitrogen-containing saturated heterocycle; L represents (1) a bond, (2) -CR^A=CR^B→ or (3) -C(=O)-NR^D→ (where in each group the arrow represents a binding site with the pyridine ring); R^A, R^B and R^D respectively and independently represent a hydrogen atom or C_1-4-alkyl; X¹ and X² respectively and independently represent a halogen atom that is an agonist to somatostatin receptor of subtype 2.

EFFECT: proposed is a compound having agonistic activity to somatostatin receptor and medicinal use thereof.

12 cl, 7 ex