FIELD: biotechnology.
SUBSTANCE: group of inventions relates to biotechnology. Modified polypeptide having sigma-factor A activity of RNA polymerase, wherein at least one amino acid selected from the group consisting of amino acids in the following positions of the polypeptide, having the amino acid sequence set forth in SEQ ID NO: 2 is substituted, and the amino acid substitution is at least one of the following amino acid substitutions: 136G, 254N, 268S, 281S, 381R, 429R, 447H, 451I, 455V, 479R, 483R, 488T and 491R. Polynucleotide encoding said modified polypeptide is provided. Microorganism is proposed, having an increased ability to produce L-lysine containing said modified polypeptide. Method for producing L-lysine using this microorganism is provided.
EFFECT: group of inventions allows to increase the production of L-lysine.
7 cl, 10 ex, 10 tbl
| Title |
Year |
Author |
Number |
| PYRUVATE DEHYDROGENASE MUTANT, MUTANT-CONTAINING MICROORGANISM, AND METHOD FOR PRODUCING L-AMINO ACID USING MICROORGANISM |
2016 |
- Song Sung Ki
- Kim Hyung Joon
- Bae Hyun Won
- Moon Jun Ok
- Huh Lan
|
RU2683208C1 |
| CORYNEBACTERIUM GENUS MICROORGANISM WITH IMPROVED ABILITY TO PRODUCE L-LYSINE AND METHOD FOR PRODUCING L-LYSINE USING SAME |
2014 |
- Moon Jun Ok
- Park Sang Hee
- Huh Lan
- Lee Kwang Ho
|
RU2651505C1 |
| METHOD FOR L-LYSINE PRODUCTION USING MICROORGANISMS CAPABLE OF L-LYSINE PRODUCTION |
2012 |
- Lee Kwang Ho
- Lim Sang Jo
- Moon Jun Ok
- Jang Jae Woo
- Park Su Jin
- Park Sang Hee
|
RU2616870C1 |
| METHOD OF PRODUCING L-LYSINE USING MICROORGANISMS, CAPABLE OF PRODUCING L-LYSINE |
2012 |
- Lee Kwang Ho
- Lim Sang Jo
- Moon Jun Ok
- Jang Jae Woo
- Park Su Jin
- Park Sang Hee
|
RU2588665C2 |
| MICROORGANISM HAVING IMPROVED L-LYSINE PRODUCING ABILITY AND METHOD FOR PRODUCING L-LYSINE BY USING SAID MICROORGANISM |
2015 |
- Lee, Peter
- Moon, Jun Ok
- Kim, Hyung Joon
- Ryu, Song Gi
|
RU2663135C2 |
| MICROORGANISM OF CORYNEBACTERIUM GENUS PRODUCING L-LYSINE, AND METHOD OF PRODUCING L-LYSINE USING SAID MICROORGANISM |
2017 |
- Byun Hyo Jeong
- Kim Hyung Joon
- Bae Hyun Won
- Ryu Song-Gi
- Choi Hyang
- Moon Jun Ok
- Lee Kyung-Chang
- Choi Yunjung
|
RU2720522C1 |
| METHOD FOR L-LYSINE PRODUCTION USING MICROORGANISMS CAPABLE OF L-LYSINE PRODUCTION |
2012 |
- Lee Kwang Ho
- Lim Sang Jo
- Moon Jun Ok
- Jang Jae Woo
- Park Su Jin
- Park Sang Hee
|
RU2615454C1 |
| MICROORGANISM CAPABLE OF PRODUCING L-LYSINE, AND A METHOD OF PRODUCING L-LYSINE USING SAID MICROORGANISM |
2015 |
- Bae Hyun Won
- Moon Jun Ok
- Song Sung Ki
- Kim Hyunhg Joon
- Kim Hyo Jin
- Lim Sang Jo
|
RU2694729C2 |
| MICROORGANISM WHICH POSSESS PRODUCTIVITY OF L-LYSINE, AND METHOD OF PRODUCING L-LYSINE USING THIS MICROORGANISM |
2016 |
- Lee Peter
- Kim Hyung Joon
- Choi Hyang
- Ryu Song Gi
- Lee Sang Mok
|
RU2683551C1 |
| MICROORGANISM OF CORYNEBACTERIUM SPECIES HAVING ENHANCED L-LYSINE PRODUCIBILITY AND METHOD FOR PRODUCING L-LYSINE USING SAME |
2014 |
- Park Sang Hee
- Moon Jun Ok
- Bae Hyun Won
- Lee Kwang Ho
|
RU2667425C2 |
