FIELD: biotechnology.
SUBSTANCE: group of inventions relates to biotechnology. Disclosed is a microorganism of the genus Corynebacterium having an enhanced ability to produce L-lysine as compared to an unmodified microorganism, in which the activity of acetate kinase is enhanced in comparison to its endogenous activity, wherein the acetate kinase has the amino acid sequence SEQ ID NO: 12. Disclosed is a method of producing L-lysine using a microorganism of the genus Corynebacterium, having an enhanced ability to produce L-lysine as compared to an unmodified microorganism, in which the activity of acetate kinase is enhanced as compared to its endogenous activity. Disclosed is use of a microorganism of the genus Corynebacterium, in which the activity of acetate kinase is enhanced as compared to its endogenous activity, for enhanced production of L-lysine.
EFFECT: group of inventions enables to produce L-lysine with high output compared to the original unmodified microorganism.
7 cl, 3 dwg, 5 tbl, 7 ex
| Title | Year | Author | Number |
|---|---|---|---|
| MICROORGANISM OF CORYNEBACTERIUM SPECIES HAVING ENHANCED L-LYSINE PRODUCIBILITY AND METHOD FOR PRODUCING L-LYSINE USING SAME | 2014 |
|
RU2667425C2 |
| Corynebacterium MICROORGANISMS, CAPABLE OF RECYCLING XYLOSE, AND METHOD OF PRODUCING L-LYSINE USING SAID MICROORGANISMS | 2013 |
|
RU2584593C2 |
| MICROORGANISMS FOR PRODUCING PUTRESCINE OR ORNITHINE AND METHOD OF PRODUCING PUTRESCINE OR ORNITHINE USING SAID MICROORGANISMS | 2016 |
|
RU2708165C2 |
| CORYNEBACTERIUM GENUS MICROORGANISM FOR PRODUCING L-LYSINE AND METHOD FOR PRODUCING L-LYSINE BY USING SAME | 2015 |
|
RU2668830C2 |
| GLUCONATE REPRESSOR VARIANT, L-LYSINE MICROORGANISM-PRODUCER THEREWITH AND METHOD FOR OBTAINING L-LYSINE BASED THEREON | 2016 |
|
RU2681475C1 |
| METHOD OF PRODUCING L-AMINO ACIDS | 2018 |
|
RU2697005C2 |
| METHOD OF PRODUCING L-AMINO ACIDS | 2014 |
|
RU2651461C2 |
| METHOD OF PRODUCING L-AMINO ACIDS | 2014 |
|
RU2614258C2 |
| MICROORGANISM WITH IMPROVED ABILITY TO PRODUCE L-LYSINE AND METHOD OF OBTAINING L-LYSINE USING THIS MICROORGANISM | 2015 |
|
RU2668176C1 |
| MICROORGANISM OF CORYNEBACTERIUM GENUS PRODUCING L-LYSINE, AND METHOD OF PRODUCING L-LYSINE USING SAID MICROORGANISM | 2017 |
|
RU2720522C1 |
