TRIPEPTIDES Russian patent published in 2018 - IPC C07K5/09 C07K5/83 C07K5/87 A61K38/05 A61P29/00 A61P37/00 

FIELD: chemistry.

SUBSTANCE: invention relates to tripeptide compounds of general formula (1), where AA¹ is selected from Lys, Orn, Nle, Phe, N^α-methyl-Phe, N^α,N^αdimethyl-Nle, N^α,N^αdimethyl-Phe and N^α,N^αdimethyl-Lys; and AA² selected from α-aminoisobutyric acid (Aib), tert-butylglycine, amide α-aminoisobutyric acid, N^α-methyl-Thr-OH, N^α-methyl-Thr-NH₂ and N^αmethyl-Val-OH, and their use as medications, in particular as anti-inflammatory agents.

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EFFECT: object of the present invention is the provision of such compounds with increased stability and improved bioavailability being at the same time safe and secure for the patients.

8 cl, 6 dwg, 9 tbl, 1 ex