FIELD: chemistry.
SUBSTANCE: invention relates to compounds of formula (I)
Formula (I) in which W is selected from CH and N; X is selected from CH, CH2-CH2, CH = CH, N and NH; Y is selected from CH2, CH, N, NH and O; in which the bond between X and Y
is either saturated, unsaturated or aromatic; B is selected from: i) a radical of formula II
(II) and ii) a condensed 6,5- or 6,6-heteroaromatic bicyclic ring structure containing N and, optionally, one or two additional heteroatoms, which are independently selected from N, which is optionally monosubstituted with NR8R9; P is H and Q is -C(R20)(R21)NH2 or P is -C(R20)(R21)NH2 and Q is H; U and V, independently of each other, are selected from C and N, thus the aromatic ring containing U and V is phenyl, pyridine or pyridazine; R1 is absent provided that U is N; R2 is absent provided that V is N; or, if present, R1 and R2, independently of one another, are selected from H and alkyl; R3 is selected from H, alkyl, alkoxy, CN, halogen and CF3; A is selected from -(CH2)0-9-heteroaryl and -(CH2)0-9-aryl; R8 and R9 are H; R20 and R21, independently of each other, are selected from H and alkyl, which are directly related to plasma kallikrein activity.
EFFECT: these compounds are potentially useful in the treatment of impaired visual acuity, diabetic retinopathy, macular edema, hereditary angioedema, diabetes, pancreatitis, cerebral haemorrhage, nephropathy, cardiomyopathy, neuropathy, inflammatory bowel disease, arthritis, inflammation, septic shock, hypotension, cancer, adult respiratory distress syndrome, disseminated intravascular coagulation, cardiopulmonary bypass surgery and bleeding from post operative surgery.
22 cl, 5 tbl, 10 ex
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Authors
Dates
2018-11-16—Published
2014-08-14—Filed