MODULATION OF SPECIFICITY OF STRUCTURED POLYPEPTIDES Russian patent published in 2018 - IPC A61K47/00 

FIELD: biotechnology.

SUBSTANCE: peptide ligand is described specific for human kallikrein, which includes a polypeptide containing at least three reactive groups separated by sequences of at least two loops, and molecular backbone forming covalent bonds with reactive groups of a polypeptide with the formation on the molecular backbone of at least two loops ofpolypeptide, peptide ligand loops include five amino acids and one loop contains a fragment G_rA(ψCH₂NH)H^Q/_TxLG_r, where G_r means reactive group. Pharmaceutical composition containing said peptide is also described and the use of said peptide for the treatment of conditions mediated by kallikrein selected from inflammatory conditions is presented, allergic hypersensitivity, cancer, bacterial or viral infection, ophthalmologic disorders and autoimmune disorders.

EFFECT: invention expands the arsenal of means of treating diseases, mediated by kallikrein.

12 cl, 23 dwg, 27 tbl, 10 ex