FIELD: chemistry.
SUBSTANCE: invention relates to polypeptides which are covalently bonded to molecular frameworks such that two or more peptide loops are closed between attachment points to the framework. In particular, the invention describes peptides which bind with high affinity to type 1 membrane metalloprotease (MT1-MMP).
EFFECT: invention also describes conjugates of drugs containing said peptides conjugated with one or more effector and/or functional groups, which are used in imaging and targeted therapy of cancer.
13 cl, 13 dwg, 17 tbl, 5 ex
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