FIELD: chemistry.
SUBSTANCE: invention relates to polypeptides which are covalently bonded to molecular frameworks such that two or more peptide loops are closed between attachment points to the framework. In particular, the invention describes peptides which bind with high affinity to type 1 membrane metalloprotease (MT1-MMP).
EFFECT: invention also describes conjugates of drugs containing said peptides conjugated with one or more effector and/or functional groups, which are used in imaging and targeted therapy of cancer.
13 cl, 13 dwg, 17 tbl, 5 ex
| Title | Year | Author | Number |
|---|---|---|---|
| NOVEL POLYPEPTIDES | 2014 |
|
RU2674604C2 |
| MODULATION OF SPECIFICITY OF STRUCTURED POLYPEPTIDES | 2014 |
|
RU2674070C2 |
| MODULATION OF STRUCTURED PROTEINS SPECIFICITY | 2012 |
|
RU2631931C2 |
| MODULATING THE SPECIFICITY OF STRUCTURED PROTEINS | 2012 |
|
RU2745572C2 |
| POLY-LIGAND MEDICINAL CONJUGATES AND USE THEREOF | 2016 |
|
RU2722449C2 |
| MODIFIED ANTIBODIES COMPOSITION, METHODS OF PRODUCTION AND APPLICATION | 2010 |
|
RU2636046C2 |
| KOVALENT-RELATED CONJUATES OF ANTIGEN-ANTIBODY | 2013 |
|
RU2684595C2 |
| COMPOSITIONS OF MODIFIED ANTIBODIES, METHODS FOR THEIR PRODUCTION AND USE | 2010 |
|
RU2799787C2 |
| MODULE MOLECULAR CONJUGATE FOR TARGETING GENETIC CONSTRUCTS AND METHOD FOR PREPARING IT | 2012 |
|
RU2529034C2 |
| MOLECULAR CONJUGATE ON BASIS OF SYNTHETIC ANALOGUES OF LULIBERIN AND APPLICATION THEREOF AS DNA DELIVERY SYSTEM TO CELLS OF HORMONE-SENSITIVE TUMOURS (VERSIONS) | 2007 |
|
RU2377247C2 |
