FIELD: medicine.
SUBSTANCE: invention relates to polypeptides which are covalently bonded to molecular scaffolds so that two or more peptide loops are closed between points of attachment to the scaffold. In particular, the invention describes peptides which bind with high affinity to type 1 membrane metalloprotease (MT1-MMP). Invention also describes drug conjugates containing said peptides conjugated with one or more effector and/or functional groups, which are used in imaging and targeted therapy of cancer.
EFFECT: bicyclic peptide ligands specific for MT1-MMP are disclosed.
30 cl, 13 dwg, 17 tbl, 5 ex
