POLYMYXIN DERIVATIVES AND THEIR USE Russian patent published in 2018 - IPC C07K7/62 A61K38/12 A61P31/04

Abstract RU 2675819 C1

FIELD: chemistry.

SUBSTANCE: invention relates to compound of formula (I) , where R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and R(FA) have the meanings indicated in claim 1 of the claims, or pharmaceutically acceptable salt. Invention also relates to a pharmaceutical composition having antibacterial activity, containing the above compound, and to a method of treating a bacterial infection through its use.

EFFECT: obtaining a new derivative of polymyxin, effective against gram-negative bacteria and with reduced nephrotoxicity.

12 cl, 4 dwg, 3 tbl, 5 ex

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RU 2 675 819 C1

Authors

Vaara Martti

Vaara Timo

Dates

2018-12-25—Published

2016-01-15—Filed