FIELD: chemistry.
SUBSTANCE: present invention relates to a polymyxin derivative having a total of three positive charges at physiological pH and where the terminal moiety (D) of the derivative contains a total of 1-5 carbon atoms; a method for production thereof; a composite product containing at least two such derivatives; a pharmaceutical composition containing a polymyxin derivative; a method of sensitising gram-negative bacteria to an antibacterial agent; a method of producing novel antibiotics.
EFFECT: invention also relates to use of the polymyxin derivative in producing a medicine for sensitising gram-negative bacteria to antibacterial agents.
23 cl, 8 tbl, 8 ex
| Title | Year | Author | Number |
|---|---|---|---|
| POLYMIXIN DERIVATIVES AND APPLICATION THEREOF | 2007 |
|
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| POLYMYXIN DERIVATIVES AND THEIR USE | 2016 |
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| POLYMYXIN DERIVATIVES AND USE THEREOF IN A COMBINED THERAPY TOGETHER WITH VARIOUS ANTIBIOTICS | 2014 |
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|
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| PEPTIDE ANTIBIOTICS AND PRODUCTION METHODS THEREOF | 2005 |
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RU2428429C2 |
| LYSINE POLYPEPTIDES ACTIVE AGAINST GRAM-NEGATIVE BACTERIA | 2016 |
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RU2724545C2 |
| BACTERIOPHAGE-DERIVED ANTIMICROBIAL POLYPEPTIDES AND THEIR USE AGAINST GRAM-NEGATIVE BACTERIA | 2019 |
|
RU2804774C2 |
| ANTIBIOTIC PEPTIDES | 2008 |
|
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| POLYPEPTIDE CONSTRUCTIONS LYSINE-ANTIMICROBIAL PEPTIDE (AMP), LYSINES, ISOLATED ENCODING POLYNUCLEOTIDES AND VARIANTS OF THEIR APPLICATION | 2019 |
|
RU2803121C2 |
| ANTIBACTERIAL PEPTIDES | 2007 |
|
RU2468033C2 |
