FIELD: medicine.
SUBSTANCE: invention relates to medicine and can be used to produce an experimental model of osteoporosis. Three-year-old sheep of the North Caucasian breed is subjected to bilateral ovariectomy. From the second day after the operation, intramuscular administration of dexamethasone is carried out for 3 months at a dose of 12 mg per 1 kg of body by 6 injections per week.
EFFECT: method provides for the creation of an experimental model of osteoporosis, which allows to exclude the mortality of experimental subjects, to obtain a model of osteoporosis with a large volume of tissues that is complete and irreversible throughout the life of the animal, available for research through the use of a three-year-old sheep of the North Caucasian breed, a bilateral ovariectomy and the most optimal regimen and dosage of dexamethasone.
1 cl, 2 dwg
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR CREATING AN EXPERIMENTAL MODEL OF PERI-IMPLANT PATHOLOGY | 2019 |
|
RU2730970C1 |
| METHOD OF OBTAINING EXPERIMENTAL MODEL OF PERIODONTITIS | 2017 |
|
RU2676649C1 |
| DENTAL GEL FOR TREATING AND PREVENTING PERIODONTITIS | 2017 |
|
RU2703530C2 |
| METHOD FOR CREATING EXPERIMENTAL MODEL OF OSTEOPOROSIS IN RABBIT | 2011 |
|
RU2480843C1 |
| METHOD FOR ACCELERATING REPARATIVE OSTEOGENESIS IN BISPHOSPHONATE OSTEONECROSIS | 2020 |
|
RU2745584C1 |
| METHOD OF ACCELERATING REPARATIVE REGENERATION OF BONE TISSUE | 2020 |
|
RU2738085C1 |
| METHOD FOR BONE TISSUE MINERAL DENSITY LOCAL DECREASE SIMULATION FOR RABBITS | 2016 |
|
RU2615902C1 |
| DEVICE FOR FIXATION OF MANDIBLE FRAGMENTS IN EXPERIMENTAL ANIMAL | 2017 |
|
RU2682615C1 |
| METHOD OF MODELING THE LOWER JAW DEFECT IN AN EXPERIMENTAL ANIMAL | 2017 |
|
RU2682613C1 |
| GLUE COMPOSITION FOR ORAL CAVITY IN TREATMENT OF PERIODONTITIS AND PERI-IMPLANTITIS | 2021 |
|
RU2791674C1 |
