NOVEL DEPOT-PREPARATIONS FOR INJECTION Russian patent published in 2007 - IPC A61K31/495 A61K47/40 A61P25/18 

FIELD: medicine, pharmacy.

SUBSTANCE: invention relates to injection depot-preparations containing ziprasidon or its pharmaceutically acceptable salts that solubilized with cyclodextrin and containing a viscosity modifying agent and comprising a cellulose derivative, polyvinylpyrrolidone, alginates, chitosan, dextran, gelatin, polyethylene glycols, polyoxyethylene ethers, polyoxypropylene ethers, polyactides, polyglycolides, polycaprolactones, polyanhydrides, polyamines, polyurethanes, polyetheramides, poly-ortho-esters, polydioxanones, polyacetals, polycarbonates, poly-ortho-carbonates, polyphosphazenes, succinates, polycarbonates, poly-(maleic acid), poly-(amino acids), polyhydroxycellulose, chitin, copolymers or terpolymers of abovementioned substances, sucrose butyrate acetate, PLGA, stearic acid/NMP or their combinations. Also, the claimed invention relates to depot-preparations containing ziprasidon mesylate and solubilized SBECD. Also, the claimed invention relates to a method for treatment of psychotic disease, for example, schizophrenia that involves using the claimed preparations. The claimed preparations provides prolonged administration of ziprasidon and its content from 70 to about 280 mgA/ml that provides possibility for a single administration and providing the therapeutic effect for prolonged period.

EFFECT: improved and valuable medicinal and pharmaceutical properties of preparations.

16 cl, 2 tbl, 2 ex