N-(3-(5-(4-CHLOROPHENYL)-1N-PYRAZOLO[3,4-B]PYRIDINE-3-CARBONYL)-2,4-DIFLUOROPHENYL)PROPANE-1-SULPHONAMIDE CRYSTALLINE FORM, ACTIVE COMPONENT, PHARMACEUTICAL COMPOSITION AND MEDICINE Russian patent published in 2019 - IPC C07D471/04 A61K31/4162 A61P35/00 

Abstract RU 2678455 C1

FIELD: chemistry.

SUBSTANCE: invention relates to the field of organic chemistry, namely to N-(3-(5-(4-chlorophenyl)-1H-pyrazolo[3,4-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propan-1-sulfonamide of formula 1 or its pharmaceutically acceptable salt. Invention also relates to a new crystalline form, an active component, a pharmaceutical composition and a drug based on compound 1.

1.

EFFECT: new compound is obtained for the prevention or treatment of proliferative diseases, characterized by BRAF kinase mutation.

10 cl, 4 dwg, 5 tbl, 10 ex

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RU 2 678 455 C1

Authors

Leonov Sergej Viktorovich

Chuprov-Netochin Roman Nikolaevich

Ivanenkov Yan Andreevich

Dates

2019-01-29Published

2018-06-01Filed