N-(3-(5-(4-CHLOROPHENYL)-1N-PYRAZOLO[3,4-B]PYRIDINE-3-CARBONYL)-2,4-DIFLUOROPHENYL)PROPANE-1-SULPHONAMIDE CRYSTALLINE FORM, ACTIVE COMPONENT, PHARMACEUTICAL COMPOSITION AND MEDICINE Russian patent published in 2019 - IPC C07D471/04 A61K31/4162 A61P35/00 

Abstract RU 2678455 C1

FIELD: chemistry.

SUBSTANCE: invention relates to the field of organic chemistry, namely to N-(3-(5-(4-chlorophenyl)-1H-pyrazolo[3,4-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propan-1-sulfonamide of formula 1 or its pharmaceutically acceptable salt. Invention also relates to a new crystalline form, an active component, a pharmaceutical composition and a drug based on compound 1.

1.

EFFECT: new compound is obtained for the prevention or treatment of proliferative diseases, characterized by BRAF kinase mutation.

10 cl, 4 dwg, 5 tbl, 10 ex

Similar patents RU2678455C1

Title Year Author Number
BRAF KINASE INHIBITOR N-(3-(5-(4-CHLOROPHENYL)-1H-PYRAZOLO[3,4-B]PYRIDIN-3-CARBONIL)-2,4-DIFLUOROPHENYL)PROPANE-1-SULFONAMIDE 2018
  • Leonov Sergej Viktorovich
  • Chuprov-Netochin Roman Nikolaevich
  • Ivanenkov Yan Andreevich
RU2687107C1
CRYSTAL SALTS OF B-RAF-KINASE INHIBITOR 2018
  • Vertman Ulrike
  • Majer Gerd-Mikhael
  • Bettsemajer Bodo
  • Shaf Otmar
RU2798091C2
4-OXO-3,4-DIHYDROQUINAZOLINONE COMPOUNDS FOR TREATMENT OF BRAF-ASSOCIATED DISEASES AND DISORDERS 2021
  • Bettendorf, Tanna Marie
  • Doerner Barbour, Patrick Michael
  • Kahn, Dean Russell
  • Kellum, Alex Andrew
  • Laird, Ellen Ruth
  • Moreno, David Austin
  • Ren, Li
RU2814662C1
COMBINED THERAPY INCLUDING VEMURAFENIB AND INTERFERON, FOR USE IN TREATING CANCER 2011
  • Dkhingra Kapil
  • Khiggins Brajan
  • Kolinski Kennet
  • Li Richard Dzh.
  • Lestini Brajan
  • Pekmen Ketrin E.
  • Su Fej
RU2592983C2
ANTICANCER THERAPEUTIC AGENT 2012
  • Narita Jusuke
  • Matsui Dzundzi
  • Funakhasi Jasukhiro
RU2580609C2
AGENT INDUCING CELL DEATH FOR CELLS HAVING BRAF GENE MUTATIONS, AGENT SUPPRESSING GROWTH OF SUCH CELLS, AND PHARMACEUTICAL COMPOSITION FOR THE THERAPY OF DISEASES CAUSED BY GROWTH DEFECT OF SUCH CELLS 2016
  • Nishita Hiroki
  • Nisita Khiroki
RU2760835C2
QUINAZOLIN-4-ONE DERIVATIVES USEFUL IN THE TREATMENT OF BRAF-ASSOCIATED DISEASES AND DISORDERS 2020
  • Barbour, Patrick Michael
  • Brown, Katie Keaton
  • Cook, Adam Wade
  • Hicken, Erik James
  • Kahn, Dean Russell
  • Laird, Ellen Ruth
  • Metcalf, Andrew Terrance
  • Moreno, David Austin
  • Newhouse, Bradley Jon
  • Pajk, Spencer Phillip
  • Prigaro, Brett Joseph
  • Ren, Li
  • Tarlton, Eugene
RU2797606C1
MKK4 PROTEIN KINASE INHIBITORS FOR STIMULATION OF LIVER REGENERATION OR REDUCTION OR PREVENTION OF HEPATOCYTE DEATH 2019
  • Praefke, Bent
  • Klefekorn, Filip
  • Zelig, Roland
  • Albrekht, Volfgang
  • Laufer, Shtefan
RU2788000C2
COMBINED ANTICANCER THERAPY 2011
  • Dkhingra Kapil
  • Khiggins Brajan
  • Kolinski Kennet
  • Li Richard Dzh.
  • Lestini Brajan
  • Pekmen Ketrin E.
  • Su Fej
RU2607596C2
NEW PAN-RAF KINASE INHIBITOR AND APPLICATIONS THEREOF 2019
  • Lyu, Tsin Sun
  • Lyu, Tszin
  • Li, Si Syan
  • Van, Ao Li
  • Tsi, Tszy Pin
  • Lyu, Tsin Van
  • Tszyan, Tszun Zhu
  • Tszou, Fen Min
  • Van, Ven Chao
  • Khu, Chen
  • Chen, Chen
  • Van, Li
RU2792626C1

RU 2 678 455 C1

Authors

Leonov Sergej Viktorovich

Chuprov-Netochin Roman Nikolaevich

Ivanenkov Yan Andreevich

Dates

2019-01-29Published

2018-06-01Filed